Selected Essigmann Lab Publications
DNA polymerase V allows bypass of toxic guanine oxidation products in vivo.
J.Biol.Chem. 282, 12741-12748 (2007).
Neeley, W. L., Delaney, S., Alekseyev, Y. O., Jarosz, D. F., Delaney, J. C., Walker, G. C., and Essigmann, J. M.
The substrate specificity of MutY for hyperoxidized guanine lesions in vivo.
Biochemistry 46, 1448-1455 (2007).
Delaney, S., Neeley, W. L., Delaney, J. C., and Essigmann, J. M.
Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB.
Proc.Natl.Acad.Sci.U.S.A 104, 755-760 (2007).
Frick, L. E., Delaney, J. C., Wong, C., Drennan, C. L., and Essigmann, J. M.
Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo.
Methods Enzymol. 408, 1-15 (2006).
Delaney, J. C. and Essigmann, J. M.
DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo.
Mol.Cancer.Ther. 5, 977-984 (2006).
Hillier, S. M., Marquis, J. C., Zayas, B., Wishnok, J. S., Liberman, R. G., Skipper, P. L., Tannenbaum, S. R., Essigmann, J. M., and Croy, R. G.
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.
Chem.Res.Toxicol. 19, 491-505 (2006).
Neeley, W. L. and Essigmann, J. M.
A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.
Nature 439, 225-228 (2006).
Jarosz, D. F., Godoy, V. G., Delaney, J. C., Essigmann, J. M., and Walker, G. C.
Probing the active site tightness of DNA polymerase in subangstrom increments.
Proc.Natl.Acad.Sci.U.S.A 102, 15803-15808 (2005).
Kim, T. W., Delaney, J. C., Essigmann, J. M., and Kool, E. T.
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.
Nat.Struct.Mol.Biol. 12, 855-860 (2005).
Delaney, J. C., Smeester, L., Wong, C., Frick, L. E., Taghizadeh, K., Wishnok, J. S., Drennan, C. L., Samson, L. D., and Essigmann, J. M.
Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli.
J.Bacteriol. 187, 7027-7037 (2005).
Robbins-Manke, J. L., Zdraveski, Z. Z., Marinus, M., and Essigmann, J. M.
Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand.
Chem.Biol. 12, 779-787 (2005).
Marquis, J. C., Hillier, S. M., Dinaut, A. N., Rodrigues, D., Mitra, K., Essigmann, J. M., and Croy, R. G.
Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations.
Chem.Res.Toxicol. 18, 12-18 (2005).
Henderson, P. T., Neeley, W. L., Delaney, J. C., Gu, F., Niles, J. C., Hah, S. S., Tannenbaum, S. R., and Essigmann, J. M.
RecN and RecG are required for Escherichia coli survival of Bleomycin-induced damage.
Mutat.Res. 554, 149-157 (2004).
Kosa, J. L., Zdraveski, Z. Z., Currier, S., Marinus, M. G., and Essigmann, J. M.
Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli.
Proc.Natl.Acad.Sci.U.S.A 101, 14051-14056 (2004).
Delaney, J. C. and Essigmann, J. M.
In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole.
J.Biol.Chem. 279, 43568-43573 (2004).
Neeley, W. L., Delaney, J. C., Henderson, P. T., and Essigmann, J. M.
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents.
Bioorg.Med.Chem.Lett. 14, 3829-3833 (2004).
Sharma, U., Marquis, J. C., Nicole, Dinaut A., Hillier, S. M., Fedeles, B., Rye, P. T., Essigmann, J. M., and Croy, R. G.
Spontaneous and cisplatin-induced recombination in Escherichia coli.
DNA Repair (Amst) 3, 719-728 (2004).
Nowosielska, A., Calmann, M. A., Zdraveski, Z., Essigmann, J. M., and Marinus, M. G.
Aflatoxin B1-formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo.
Carcinogenesis 25, 1045-1051 (2004).
Alekseyev, Y. O., Hamm, M. L., and Essigmann, J. M.
Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: generation by a postsynthetic substitution reaction.
Org.Lett. 6, 245-248 (2004).
Neeley, W. L., Henderson, P. T., and Essigmann, J. M.
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo.
Biochemistry 42, 9257-9262 (2003).
Henderson, P. T., Delaney, J. C., Muller, J. G., Neeley, W. L., Tannenbaum, S. R., Burrows, C. J., and Essigmann, J. M.
High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds.
Proc.Natl.Acad.Sci.U.S.A 100, 4469-4473 (2003).
Delaney, J. C., Henderson, P. T., Helquist, S. A., Morales, J. C., Essigmann, J. M., and Kool, E. T.
The aflatoxin B1-formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma.
Proc.Natl.Acad.Sci.U.S.A 99, 6655-6660 (2002).
Smela, M. E., Hamm, M. L., Henderson, P. T., Harris, C. M., Harris, T. M., and Essigmann, J. M.
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells.
J.Am.Chem.Soc. 124, 1862-1863 (2002).
Mitra, K., Marquis, J. C., Hillier, S. M., Rye, P. T., Zayas, B., Lee, A. S., Essigmann, J. M., and Croy, R. G.
Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo.
Biochemistry 41, 914-921 (2002).
Henderson, P. T., Delaney, J. C., Gu, F., Tannenbaum, S. R., and Essigmann, J. M.
MutS preferentially recognizes cisplatin- over oxaliplatin-modified DNA.
J.Biol.Chem. 277, 1255-1260 (2002).
Zdraveski, Z. Z., Mello, J. A., Farinelli, C. K., Essigmann, J. M., and Marinus, M. G.
Design of DNA damaging agents that hijack transcription factors and block DNA repair.
Adv.Exp.Med.Biol. 500, 301-313 (2001).
Essigmann, J. M., Rink, S. M., Park, H. J., and Croy, R. G.
Effect of sequence context on O6-methylguanine repair and replication in vivo.
Biochemistry 40, 14968-14975 (2001).
Delaney, J. C. and Essigmann, J. M.
Mechanisms of resistance to cisplatin.
Mutat.Res. 478, 23-43 (2001).
Kartalou, M. and Essigmann, J. M.
Recognition of cisplatin adducts by cellular proteins.
Mutat.Res. 478, 1-21 (2001).
Kartalou, M. and Essigmann, J. M.
The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis.
Carcinogenesis 22, 535-545 (2001).
Smela, M. E., Currier, S. S., Bailey, E. A., and Essigmann, J. M.
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA.
Biochemistry 40, 6653-6659 (2001).
Eide, L., Luna, L., Gustad, E. C., Henderson, P. T., Essigmann, J. M., Demple, B., and Seeberg, E.
Cisplatin adducts inhibit 1,N6-ethenoadenine repair by interacting with the human 3-methyladenine DNA glycosylase.
Biochemistry 39, 8032-8038 (2000).
Kartalou, M., Samson, L. D., and Essigmann, J. M.
Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease.
J.Biol.Chem. 275, 26632-26636 (2000).
Kuraoka, I., Kobertz, W. R., Ariza, R. R., Biggerstaff, M., Essigmann, J. M., and Wood, R. D.
Multiple pathways of recombination define cellular responses to cisplatin.
Chem.Biol. 7, 39-50 (2000).
Zdraveski, Z. Z., Mello, J. A., Marinus, M. G., and Essigmann, J. M.
Context-dependent mutagenesis by DNA lesions.
Chem.Biol. 6, 743-753 (1999).
Delaney, J. C. and Essigmann, J. M.
Lethal mutagenesis of HIV with mutagenic nucleoside analogs.
Proc.Natl.Acad.Sci.U.S.A 96, 1492-1497 (1999).
Loeb, L. A., Essigmann, J. M., Kazazi, F., Zhang, J., Rose, K. D., and Mullins, J. I.
Cisplatin.
Essays Biochem 34, 191-211 (1999).
Trimmer, E. E. and Essigmann, J. M.
Substrate specificity of ultraviolet DNA endonuclease (UVDE/Uve1p) from Schizosaccharomyces pombe.
Nucleic Acids Res 27, 2256-2264 (1999).
Avery, A. M., Kaur, B., Taylor, J. S., Mello, J. A., Essigmann, J. M., and Doetsch, P. W.
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage.
Biochemistry 38, 6204-6212 (1999).
Cullinane, C., Mazur, S. J., Essigmann, J. M., Phillips, D. R., and Bohr, V. A.
Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.
J Biol Chem 274, 8516-8523 (1999).
Pourquier, P., Ueng, L. M., Fertala, J., Wang, D., Park, H. J., Essigmann, J. M., Bjornsti, M. A., and Pommier, Y.
Cisplatin-DNA adducts inhibit ribosomal RNA synthesis by hijacking the transcription factor human upstream binding factor.
Biochemistry 37, 16307-16315 (1998).
Zhai, X., Beckmann, H., Jantzen, H. M., and Essigmann, J. M.
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions.
Mutat.Res. 400, 99-115 (1998).
Wang, D., Kreutzer, D. A., and Essigmann, J. M.
Oxidized, deaminated cytosines are a source of C ® T transitions in vivo.
Proc.Natl.Acad.Sci.U.S.A 95, 3578-3582 (1998).
Kreutzer, D. A. and Essigmann, J. M.
Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities.
Biochemistry 37, 352-362 (1998).
Trimmer, E. E., Zamble, D. B., Lippard, S. J., and Essigmann, J. M.
Mass spectral identification and positional mapping of aflatoxin B1-guanine adducts in oligonucleotides.
J Am Soc Mass Spectrom. 9, 676-682 (1998).
Marzilli, L. A., Wang, D., Kobertz, W. R., Essigmann, J. M., and Vouros, P.
An efficient synthesis of a furan-side furocoumarin thymidine monoadduct.
J.Org.Chem. 62, 2630-2632 (1997).
Kobertz, W. R. and Essigmann, J. M.
Synthesis of oligonucleotides containing two putatively mutagenic DNA lesions: 5-hydroxy-2'-deoxyuridine and 5-hydroxy-2'-deoxycytidine.
Chem.Res.Toxicol. 10, 1345-1350 (1997).
Morningstar, M. L., Kreutzer, D. A., and Essigmann, J. M.
An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.
Proc.Natl.Acad.Sci.U.S.A 94, 9579-9584 (1997).
Kobertz, W. R., Wang, D., Wogan, G. N., and Essigmann, J. M.
Kinetics of oxidized cytosine repair by endonuclease III of Escherichia coli.
Biochemistry 36, 8628-8633 (1997).
Wang, D. and Essigmann, J. M.
Specificity of mutagenesis by 4-aminobiphenyl: mutations at G residues in bacteriophage M13 DNA and G ® C transversions at a unique dG(8-ABP) lesion in single-stranded DNA.
Carcinogenesis 18, 2403-2414 (1997).
Verghis, S. B., Essigmann, J. M., Kadlubar, F. F., Morningstar, M. L., and Lasko, D. D.
Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor.
Proc.Natl.Acad.Sci.U.S.A 93, 15063-15068 (1996).
Rink, S. M., Yarema, K. J., Solomon, M. S., Paige, L. A., Tadayoni-Rebek, B. M., Essigmann, J. M., and Croy, R. G.
The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin.
Chem.Biol. 3, 579-589 (1996).
Mello, J. A., Acharya, S., Fishel, R., and Essigmann, J. M.
Mutational properties of the primary aflatoxin B1-DNA adduct.
Proc.Natl.Acad.Sci.U.S.A 93, 1535-1539 (1996).
Bailey, E. A., Iyer, R. S., Stone, M. P., Harris, T. M., and Essigmann, J. M.
Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds.
Chem Res Toxicol. 9, 980-987 (1996).
Altshuler, K. B., Hodes, C. S., and Essigmann, J. M.
Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.
J Biol Chem 271, 18368-18374 (1996).
Solomon, M. S., Morgenthaler, P. M., Turesky, R. J., and Essigmann, J. M.
A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site.
Nucleic Acids Res 24, 2821-2828 (1996).
Bailey, E. A., Iyer, R. S., Harris, T. M., and Essigmann, J. M.
Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1,3-intrastrand d(GpTpG)-cisplatin adduct.
J Biol Chem 271, 7177-7186 (1996).
Moggs, J. G., Yarema, K. J., Essigmann, J. M., and Wood, R. D.
DNA adducts of cis-diamminedichloroplatinum(II) and its trans isomer inhibit RNA polymerase II differentially in vivo.
Biochemistry 34, 14783-14791 (1995).
Mello, J. A., Lippard, S. J., and Essigmann, J. M.
Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).
Nucleic Acids Res. 23, 4066-4072 (1995).
Yarema, K. J., Lippard, S. J., and Essigmann, J. M.
Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein.
Mol Cell Biol 15, 989-996 (1995).
McGoldrick, J. P., Yeh, Y. C., Solomon, M., Essigmann, J. M., and Lu, A. L.
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine.
Proc Natl Acad Sci U S A 92, 719-723 (1995).
Lipscomb, L. A., Peek, M. E., Morningstar, M. L., Verghis, S. M., Miller, E. M., Rich, A., Essigmann, J. M., and Williams, L. D.
Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).
Proc.Natl.Acad.Sci.U.S.A 91, 5672-5676 (1994).
Treiber, D. K., Zhai, X., Jantzen, H. M., and Essigmann, J. M.
Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.
J.Mol.Biol. 236, 1034-1048 (1994).
Yarema, K. J., Wilson, J. M., Lippard, S. J., and Essigmann, J. M.
Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.
Biochemistry 32, 12793-12801 (1993).
Basu, A. K., Wood, M. L., Niedernhofer, L. J., Ramos, L. A., and Essigmann, J. M.
Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II).
Biochemistry 32, 982-988 (1993).
Bradley, L. J., Yarema, K. J., Lippard, S. J., and Essigmann, J. M.
The relationship between the chemical structures and mutagenic specificities of the DNA lesions formed by chemical and physical mutagens.
Toxicol.Lett 67, 29-39 (1993).
Essigmann, J. M. and Wood, M. L.
Detection of oxidative damage by 32P-postlabelling: 8-hydroxydeoxyguanosine as a marker of exposure.
IARC Sci Publ.105-114 (1993).
Povey, A. C., Wilson, V. L., Weston, A., Doan, V. T., Wood, M. L., Essigmann, J. M., and Shields, P. G.
Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli.
Nucleic Acids Res. 20, 6023-6032 (1992).
Wood, M. L., Esteve, A., Morningstar, M. L., Kuziemko, G. M., and Essigmann, J. M.
An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.
Proc.Natl.Acad.Sci.U.S.A 89, 10772-10776 (1992).
Szymkowski, D. E., Yarema, K., Essigmann, J. M., Lippard, S. J., and Wood, R. D.
Replication inhibition and translesion synthesis on templates containing site-specifically placed cis-diamminedichloroplatinum(II) DNA adducts.
Biochemistry 31, 3975-3990 (1992).
Comess, K. M., Burstyn, J. N., Essigmann, J. M., and Lippard, S. J.
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.
Proc.Natl.Acad.Sci.U.S.A 89, 2307-2311 (1992).
Bruhn, S. L., Pil, P. M., Essigmann, J. M., Housman, D. E., and Lippard, S. J.
An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts.
Nucleic Acids Res 20, 5805-5810 (1992).
Treiber, D. K., Chen, Z., and Essigmann, J. M.
Comparative mutagenesis of O6-methylguanine and O4-methylthymine in Escherichia coli.
Biochemistry 30, 7027-7033 (1991).
Dosanjh, M. K., Singer, B., and Essigmann, J. M.
3-Methyladenine mutagenesis under conditions of SOS induction in Escherichia coli.
Carcinogenesis 12, 2283-2289 (1991).
Chaudhuri, I. and Essigmann, J. M.
Site-specific mutagenesis: retrospective and prospective.
Carcinogenesis 12, 949-955 (1991).
Singer, B. and Essigmann, J. M.
NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (edA) opposite deoxyguanosine in a DNA duplex. edA(syn)·dG(anti) pairing at the lesion site.
Biochemistry 30, 1828-1835 (1991).
de los Santos, C., Kouchakdjian, M., Yarema, K., Basu, A., Essigmann, J., and Patel, D. J.
NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (edA) opposite thymidine in a DNA duplex. Nonplanar alignment of edA(anti) and dT(anti) at the lesion site.
Biochemistry 30, 1820-1828 (1991).
Kouchakdjian, M., Eisenberg, M., Yarema, K., Basu, A., Essigmann, J., and Patel, D. J.
Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.
J Biol Chem 266, 2767-2771 (1991).
Sassanfar, M., Dosanjh, M. K., Essigmann, J. M., and Samson, L.
Effect of the antitumor drug cis-diamminedichloroplatinum(II) and related platinum complexes on eukaryotic DNA replication.
Biochemistry 29, 8461-8466 (1990).
Heiger-Bernays, W. J., Essigmann, J. M., and Lippard, S. J.
Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.
Biochemistry 29, 7024-7032 (1990).
Wood, M. L., Dizdaroglu, M., Gajewski, E., and Essigmann, J. M.
Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin.
Biochemistry 29, 5872-5880 (1990).
Donahue, B. A., Augot, M., Bellon, S. F., Treiber, D. K., Toney, J. H., Lippard, S. J., and Essigmann, J. M.
Site-specifically alkylated oligodeoxynucleotides: probes for mutagenesis, DNA repair and the structural effects of DNA damage.
Mutat.Res 233, 189-201 (1990).
Basu, A. K. and Essigmann, J. M.
Comparative efficiency of forming m4T·G versus m4T·A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase alpha-primase complex.
Biochemistry 29, 4698-4703 (1990).
Dosanjh, M. K., Essigmann, J. M., Goodman, M. F., and Singer, B.
The role of carcinogen DNA adduct structure in the induction of mutations.
Prog.Clin.Biol Res 340A, 51-60 (1990).
Loechler, E. L., Benasutti, M., Basu, A. K., Green, C. L., and Essigmann, J. M.
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.
Proc.Natl.Acad.Sci.U.S.A 86, 8620-8624 (1989).
Ellison, K. S., Dogliotti, E., Connors, T. D., Basu, A. K., and Essigmann, J. M.
Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II).
Proc.Natl.Acad.Sci.U.S.A 86, 8328-8332 (1989).
Toney, J. H., Donahue, B. A., Kellett, P. J., Bruhn, S. L., Essigmann, J. M., and Lippard, S. J.
Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.
Proc Natl Acad Sci U S A 86, 8271-8274 (1989).
Singer, B., Chavez, F., Goodman, M. F., Essigmann, J. M., and Dosanjh, M. K.
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Proc Natl Acad Sci U S A 86, 7677-7681 (1989).
Basu, A. K., Loechler, E. L., Leadon, S. A., and Essigmann, J. M.
Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis.
J Bacteriol 171, 4170-4177 (1989).
Couto, L. B., Chaudhuri, I., Donahue, B. A., Demple, B., and Essigmann, J. M.
Construction of a shuttle vector containing a single O6-methylguanine: a probe for mutagenesis in mammalian cells.
Mutat.Res 220, 93-100 (1989).
Ellison, K. S., Dogliotti, E., and Essigmann, J. M.
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
Ann.Ist.Super.Sanita 25, 155-161 (1989).
Essigmann, J. M., Basu, A. K., and Loechler, E. L.
Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion.
J.Biol.Chem. 263, 15429-15435 (1988).
Lasko, D. D., Harvey, S. C., Malaikal, S. B., Kadlubar, F. F., and Essigmann, J. M.
Chemical and biological studies of the major DNA adduct of cis-diamminedichloroplatinum(II), cis-[Pt(NH3)2{d(GpG)}], built into a specific site in a viral genome.
Biochemistry 27, 4357-4367 (1988).
Naser, L. J., Pinto, A. L., Lippard, S. J., and Essigmann, J. M.
O6-alkyldeoxyguanosine detection by 32P-postlabeling and nucleotide chromatographic analysis.
Cancer Res 48, 2156-2161 (1988).
Wilson, V. L., Basu, A. K., Essigmann, J. M., Smith, R. A., and Harris, C. C.
Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents.
Chem Res Toxicol. 1, 1-18 (1988).
Basu, A. K. and Essigmann, J. M.
Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon.
Biochemistry 26, 5626-5635 (1987).
Basu, A. K., Niedernhofer, L. J., and Essigmann, J. M.
A probe for the mutagenic activity of the carcinogen 4-aminobiphenyl: synthesis and characterization of an M13mp10 genome containing the major carcinogen-DNA adduct at a unique site.
Biochemistry 26, 3072-3081 (1987).
Lasko, D. D., Basu, A. K., Kadlubar, F. F., Evans, F. E., Lay, J. O., Jr., and Essigmann, J. M.
Repair of oligodeoxynucleotides containing O6-methylguanine by O6-alkylguanine-DNA-alkyltransferase.
Carcinogenesis 7, 1383-1386 (1986).
Scicchitano, D., Jones, R. A., Kuzmich, S., Gaffney, B., Lasko, D. D., Essigmann, J. M., and Pegg, A. E.
Mutagenesis and repair of O6-substituted guanines.
IARC Sci Publ.393-399 (1986).
Essigmann, J. M., Loechler, E. L., and Green, C. L.
Genetic toxicology of O6-methylguanine.
Prog.Clin.Biol Res 209A, 433-440 (1986).
Essigmann, J. M., Loechler, E. L., and Green, C. L.
Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates.
Cancer Res 45, 6113-6118 (1985).
Rouet, P. and Essigmann, J. M.
Extrachromosomal probes for mutagenesis by carcinogens: studies on the mutagenic activity of O6-methylguanine built into a unique site in a viral genome.
Environ Health Perspect. 62, 171-176 (1985).
Essigmann, J. M., Fowler, K. W., Green, C. L., and Loechler, E. L.
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
Proc.Natl.Acad.Sci.U.S.A 81, 6271-6275 (1984).
Loechler, E. L., Green, C. L., and Essigmann, J. M.
Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.
Proc.Natl.Acad.Sci.U.S.A 81, 13-17 (1984).
Green, C. L., Loechler, E. L., Fowler, K. W., and Essigmann, J. M.
Interactions of aflatoxin B1 and alkylating agents with DNA: structural and functional studies.
Cold Spring Harb.Symp.Quant.Biol 47 Pt 1, 327-337 (1983).
Essigmann, J. M., Green, C. L., Croy, R. G., Fowler, K. W., Buchi, G. H., and Wogan, G. N.
Aflatoxin B1: correlations of patterns of metabolism and DNA modification with biological effects.
Basic Life Sci 24, 49-62 (1983).
Croy, R. G., Essigmann, J. M., and Wogan, G. N.
Metabolic activation of aflatoxin B1: patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis.
Drug Metab Rev 13, 581-602 (1982).
Essigmann, J. M., Croy, R. G., Bennett, R. A., and Wogan, G. N.
Excretion of an aflatoxin-guanine adduct in the urine of aflatoxin B1-treated rats.
Cancer Res 41, 650-654 (1981).
Bennett, R. A., Essigmann, J. M., and Wogan, G. N.
Use of the isolated perfused rat liver to study carcinogen-DNA adduct formation from aflatoxin B1 and sterigmatocystin.
Cancer Res 40, 4085-4091 (1980).
Essigmann, J. M., Donahue, P. R., Story, D. L., Wogan, G. N., and Brunengraber, H.
Efficacy of inactivation of representative chemical carcinogens utilizing commercial alkaline and acidic cage washing compounds.
J Environ Pathol.Toxicol. 4, 97-105 (1980).
Fox, J. G., Donahue, P. R., and Essigmann, J. M.
Metabolism of aflatoxin B1, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colon.
Teratog.Carcinog.Mutagen. 1, 3-13 (1980).
Autrup, H., Schwartz, R. D., Essigmann, J. M., Smith, L., Trump, B. F., and Harris, C. C.
Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella typhimurium.
Proc.Natl.Acad.Sci.U.S.A 76, 1343-1347 (1979).
Stark, A. A., Essigmann, J. M., Demain, A. L., Skopek, T. R., and Wogan, G. N.
Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro.
Proc.Natl.Acad.Sci.U.S.A 76, 179-183 (1979).
Essigmann, J. M., Barker, L. J., Fowler, K. W., Francisco, M. A., Reinhold, V. N., and Wogan, G. N.
Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon.
Cancer Res 39, 694-698 (1979).
Autrup, H., Essigmann, J. M., Croy, R. G., Trump, B. F., Wogan, G. N., and Harris, C. C.
Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver.
Proc.Natl.Acad.Sci.U.S.A 75, 1745-1749 (1978).
Croy, R. G., Essigmann, J. M., Reinhold, V. N., and Wogan, G. N.
Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.
Proc.Natl.Acad.Sci.U.S.A 74, 1870-1874 (1977).
Essigmann, J. M., Croy, R. G., Nadzan, A. M., Busby, W. F., Jr., Reinhold, V. N., Buchi, G., and Wogan, G. N.
Quantitative determination of transfer RNA base composition using high-pressure liquid chromatography.
Anal.Biochem 81, 384-394 (1977).
Essigmann, J. M., Busby, W. F., Jr., and Wogan, G. N.